In June 1971, Irish brothers Frank and William Stephenson, who were both animal trainers, approached Texas billionaire Ross Perot about financing an animal park they wanted to open “somewhere on the East Coast of the United States”. The Stephensons and Perot formed the company C.T. Industries, Inc. to build and run the park. Ultimately, they narrowed their decision down to the D.C. area, and purchased 280 acres (110 ha) of land in Prince George's County, Maryland. On December 22, 1971, they applied to the Prince George's County planning board for a special zoning exception. The park was announced to the public in February 1972, with a projected opening before the end of that year.

In 1973, plans for the park were taken-over by ABC’s Scenic & Wildlife Attractions division (ABCSWA). On April 28, 1973, John E. Campbell (ABCSWA President) confirmed they were negotiating the purchase of another 125 acres (51 ha) for the park.

The Wildlife Preserve, a drive-through wildlife park, opened on Monday, July 15, 1974. Initially, estimated attendance was approximately 850,000 visitors a year. However, those reasonably ambitious attendance numbers never materialized. In 1975, the park added narrated tours through four-car, 150-person-capacity shuttle trains. However, the park failed to promote itself, effectively enough, to generate public interest or profits. In an effort to save-face, ABCSWA announced a $30m amusement park expansion to the struggling drive-through safari (around $171.6m in 2023).

Plans for the expansion were scrapped, and, in February 1976, it was announced that the park would close permanently. ABCSWA released a statement, claiming that the park had experienced “unacceptable attendance and revenues” in 1974 and 1975; The Wildlife Preserve itself was said to be a $4m liability for ABC, for the year 1975 (approximately $22.8m in 2023).

The park stayed open with a decreased staff in 1977, but was closed altogether for the 1978 season.

Before the year 1978 came to an end, however, the park was sold to Jim Fowler, the host of Wild Kingdom. For the 1979 season, the park reopened with a guided train tour through the safari exhibits, and a smaller park with a children's playground, animal shows, and a petting zoo. Alas, the park continued to flounder in terms of public interest, yet nevertheless remained operational for the summer, through the 1979 season. Fowler's company ultimately bowed out as well. The park again was closed for the 1980 season.

In the summer of 1980, the safari was sold to a group of local businessmen, who invested $11 million into expanding the park. The animal drive-through safari remained, and the park added three flat rides, two kid's rides and a carousel. The park was named Wild World and open by June 26, 1982. In addition to the select amusement rides, four tube waterslides were added, along with two body slides and a children's water play area. This brought modest improvements in revenue.

The 1983 season saw the addition of four more flat rides, including the High Seas (a swinging pirate ship attraction) and giant swings. The waterslide area was expanded, at the time, to a full water park; with the addition of more water slides and a large wave pool, a more successful 1983 season was underway. Dubbed the 'Wild Wave', $2 million was spent adding the wave pool and it officially opened May 30 for the 1983 season.

Tragically, a 9-year-old boy named Christie Davis died late that summer while in the wave pool, which resulted in operational safety changes. The park's attendance had improved, but the park was still unable to break-even. During the 1983 season, the safari was closed; instead, a guided train tour would pass through a few of the animal areas, stop at Safari Village, and tour the rest of the animal exhibits, before arriving back at the station. The Safari Village featured elephant, camel and pony rides, a petting zoo, various eateries, arts-and-crafts, and games; the crowd favorite, “Guess Your Age Or Weight” (featuring Regina Williams), proved so popular that it was relocated to the main park. The animals were sold and moved after the 1983 season ended. In 1984, most of the adult rides were removed from the park and held in storage, leaving only three, plus a few of the children's rides. The park opted to move in the direction of being solely a water park. A new stadium was built that year, along with several more water slides. The park would perform very well on hot days, but faltered a bit more in cooler weather, due to the shift in predominantly swimming- and water-based attractions.

In 1985, the rides were therefore brought back out of storage. That year, Wild World's management wanted to build a major wooden rollercoaster for the park in the 1986 season, but the costs were too high. There was widespread opposition to the plan from the surrounding community. In addition to adding a roller coaster, the park intended to add a 3000-seat amphitheater, and an overnight campground for guests.

At the time, Knoebels (amusement park in Pennsylvania) had acquired a used rollercoaster, Phoenix, from a defunct park in Texas; Wild World's management team was inspired and began looking for a used coaster for Wild World. With Massachusetts’ Paragon Park closing at the end of 1984, their “Giant Coaster”, which had operated since 1917, was for-sale; in the spring of 1985, Wild World acquired the old PTC coaster, rebranding it “The Wild One” and placing it in an area of the former animal park. The coaster opened in the spring of 1986 to very positive public reviews, and is still running to this day. A kiddie coaster was added to the park at the same time.

For the 1987 season, Wild World added another water play area and a lazy river. In 1988, the park would see a renovation to its buildings and midways, and a few new flat rides. In 1989, a log flume was added, along with a family raft waterslide in the waterpark. In 1990, the park began to have maintenance issues with many of their carnival-style flat rides, with several unable to be repaired. In 1991, only nine flat rides remained and the park was ultimately put up for sale.

In 1992, Wild World was purchased by Tierco Group Inc., later known as Premier Parks, which renamed the park Adventure World. That year several flat rides and a few kiddie rides were added. In 1993, Adventure World added its second adult rollercoaster. Premier Parks had acquired Lightning Loops from Six Flags. This was a dual-track steel single looping shuttle coaster located at Six Flags Great Adventure. One of the tracks was sent to Premier Parks' Frontier City located in Oklahoma City (where it still operates today as the Diamondback), while the other track became known as the Python and would be located at Adventure World. Also, a water ride called Shipwreck Falls, in which a 15-person boat would run up a steel track and down a 45-foot (14 m) drop into a splashwater pool, was added. More flat rides were added in 1994. By this time, the new additions were well-received, shown as Inside Track Magazine named Adventure World as the most improved amusement park in the country for a third consecutive year in 1994.

On May 20, 1995, Vekoma's first Mind Eraser, an inverted looping suspended coaster, opened. This was branded a SLC. In 1996, a free-fall drop-tower ride called the Tower of Doom, now known as Voodo Drop, made by Intamin was added. In 1997, the park added a second dry water ride called Typhoon Sea Coaster, which was a log flume/junior rollercoaster hybrid. It was later renamed Skull Mountain and eventually closed in July 2011 to make room for a new roller coaster. In 1997, the water park was renovated, eliminating some older slides, adding newer slides and extensively remodeling the children's water play area.

Premier Parks acquired the Six Flags amusement park chain from Time Warner in April 1998, forming the company Six Flags Incorporated. The same year, a wooden roller coaster called Roar, which was built and designed by Great Coasters International, was added to Adventure World. At the end of 1998 season, Six Flags announced that Adventure World would be branded with the Six Flags theme and renamed Six Flags America for the 1999 season. The park was officially renamed Six Flags America on October 28, 1998, and a large gala was thrown at the park to commemorate the change. Carrot cake was served in honor of Bugs Bunny the new mascot for the park. The name change allowed for the park to utilize the Looney Tunes and DC characters in its marketing.

Other changes included the addition of Gotham City, a new DC comics-themed section in the park named after the fictional city, and three new coasters – Two Face: The Flip Side, The Joker's Jinx (the park's only launched roller coaster), and Great Chase replacing Cannonball in the kiddie area. Python was closed and moved into storage.

For the 2000 season, a new hypercoaster called Superman: Ride of Steel from Intamin opened. Its layout is a mirror image of Six Flags Darien Lake's Ride of Steel which opened the previous year. The next year on June 16, the park opened Batwing, a Batman-themed Vekoma flying coaster located in the Gotham City area. A bungee ride called Skycoaster also opened in the area in 2001. Several flat rides were added in 2002 and a river rapids ride called Blizzard River was added in 2003. In 2005, the Paradise Island water park was upgraded and retitled Six Flags Hurricane Harbor. The transition from Paradise Island to Hurricane Harbor saw the addition of a new Tornado water slide as well as renovations to existing attractions and buildings. Tony Hawk's Halfpipe water slide was added in 2008.

In 2010, Six Flags America renovated the Hurricane Bay wave pool deck, adding a new stamped, concrete deck and additional shading. Also the same year, the Thomas Town family area opened featuring eight rides and attractions all themed to Thomas the Tank Engine. The 3.5-acre (14,000 m2) area was billed as North America's largest Thomas Town and marked Six Flags America's largest expansion in more than a decade. Several months later, Six Flags would announce the removal of several licensed agreements as a result of restructuring following the company's emergence from bankruptcy. Thomas the Tank Engine, Tony Hawk, The Wiggles and Evel Knievel themes would be removed from all Six Flags parks beginning in 2011. At Six Flags America, Thomas Town was renamed Whistlestop Park and Tony Hawk's Halfpipe slide was renamed Halfpipe.

For 2012, the park added Apocalypse, a stand-up roller coaster from Bolliger & Mabillard, which featured two inversions and a ten-story drop. The roller coaster had previously operated as Iron Wolf at Six Flags Great America.

In 2013, the park added the six-slide complex Bonzai Pipelines to Hurricane Harbor.

In 2014, Six Flags re-themed a section of the park to feature Mardi Gras. The area would feature a new roller coaster named Ragin' Cajun and a set of Flying Scooters named French Quarter Flyers. Like Apocalypse, Ragin' Cajun was relocated from Six Flags Great America and it was placed in the former location of Two Face: The Flip Side which was removed from the park in 2007. The Mardi Gras section replaced Southwest Territory and the area's existing rides were rethemed to match the new Mardi Gras theme. Tower of Doom, for example, was renamed Voodoo Drop.

In 2015, a flat ride called Bourbon Street Fireball was added. This ride is commonly known as a Super Loop. Similar rides were also added to three other Six Flags parks.

In 2016, Six Flags America added a new family water play structure to Hurricane Harbor named Splashwater Falls, which replaced the former Crocodile Cal's Beach House.

Six Flags America announced on September 1, 2016, that they would be adding a Funtime Starflyer model, similar to the many SkyScreamer rides at other locations in the chain. At 24 stories (~250-foot (76 m)), Wonder Woman: Lasso of Truth is the tallest ride in the park.

Announced in August 2018, Apocalypse was converted into a floorless coaster and renamed Firebird for the 2019 season.

In 2023, the park announced that the park's Hurricane Harbor water park (now named Hurricane Harbor Maryland) would receive RipQurl Blaster, the DMV's tallest water coaster.

In July 2024, parent company Six Flags and amusement park owner and operator Cedar Fair merged. After the merger, the newly formed Six Flags Entertainment Corporation outlined plans in their first quarterly earnings meeting for a portfolio optimization in the company, which may include closing or selling off some of its locations. A spokesperson from the company after the announcement a day later, stated that the company has no plans to close parks. Roughly six months later on May 1, 2025, Six Flags announced in a press release that it would be closing Six Flags America as part of its ongoing portfolio optimization program. The park scheduled its final operating day as November 2, 2025. No announcements in the press release were made on the status of the attractions in the park after closing.